Over-expression of calpastatin aggravates cardiotoxicity induced by doxorubicin
نویسندگان
چکیده
منابع مشابه
Over-expression of calpastatin aggravates cardiotoxicity induced by doxorubicin.
AIMS Doxorubicin causes damage to the heart, which may present as cardiomyopathy. However, the mechanisms by which doxorubicin induces cardiotoxicity remain not fully understood and no effective prevention for doxorubicin cardiomyopathy is available. Calpains, a family of calcium-dependent thiol-proteases, have been implicated in cardiovascular diseases. Their activities are tightly controlled ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2013
ISSN: 1755-3245,0008-6363
DOI: 10.1093/cvr/cvt048